Structure of the Actin-Tropomyosin-TNT Complex
نویسندگان
چکیده
منابع مشابه
Structure of the Rigor Actin-Tropomyosin-Myosin Complex
Regulation of myosin and filamentous actin interaction by tropomyosin is a central feature of contractile events in muscle and nonmuscle cells. However, little is known about molecular interactions within the complex and the trajectory of tropomyosin movement between its "open" and "closed" positions on the actin filament. Here, we report the 8 Å resolution structure of the rigor (nucleotide-fr...
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15 صفحه اولTropomyosin keeps actin tough
Actin (green) and ADF/cofilin (red) are disorganized in the absence of tropomyosin (bottom). ntracellular parasites must walk a fine line, invading and exploiting a host cell without killing it too quickly. On page 1029, Glomski et al. show how a single amino acid determines not only the pH I optimum of a bacterial hemolysin, but also the virulence of an important pathogen. The data help explai...
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Tropomyosin (Tm) binds along actin filaments and is a universal regulator of filament function. Mutations cause myopathies and certain forms are down-regulated in cancer cells. In muscle, with troponin Tm makes contraction Ca2+-dependent. In non-muscle cells Tm stabilizes actin filaments and protects them from branching, severing and most crosslinking. Tropomyosins enhance formin-nucleated poly...
متن کاملThe binding dynamics of tropomyosin on actin.
We discuss a theoretical model for the cooperative binding dynamics of tropomyosin to actin filaments. Tropomyosin binds to actin by occupying seven consecutive monomers. The model includes a strong attraction between attached tropomyosin molecules. We start with an empty lattice and show that the binding goes through several stages. The first stage represents fast initial binding and leaves ma...
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ژورنال
عنوان ژورنال: Biophysical Journal
سال: 2020
ISSN: 0006-3495
DOI: 10.1016/j.bpj.2019.11.233